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quinupristin/dalfopristin will enhance the degree or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
As a result of lengthy-performing metabolite, not regarded a drug of option during the elderly; linked to falls
Cessation of benzodiazepines or other CNS depressants is most popular typically. In some instances, checking at an increased volume of care for tapering CNS depressants may be ideal. In Other folks, steadily tapering a affected person off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest productive dose might be appropriate.
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Monitor Closely (one)belzutifan will lessen the level or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
diazepam will improve the level or impact of flibanserin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Enhanced flibanserin adverse consequences may possibly happen if coadministered with numerous weak CYP3A4 inhibitors.
Convey the diazepam packet or leaflet within it, any remaining medication, and another medicines you take.
Should you be Expecting, your name could possibly be mentioned over a pregnancy registry to trace the effects of diazepam on the newborn.
grapefruit will boost the stage or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
fentanyl iontophoretic transdermal system and diazepam each improve sedation. Prevent or Use Alternate Drug. Limit use to people for whom alternative treatment selections are inadequate
Diazepam is usually made use of intermittently with the prevention of febrile seizures that could manifest in kids beneath 5 years of age.[19] Recurrence prices are reduced, but Unintended effects are common so the decision to take care of febrile seizures (which happen to be benign in character) with medication ought to use this as Component of the analysis.
Reserve concomitant prescribing of those prescription drugs in individuals for whom other remedy possibilities are insufficient. Restrict dosages and durations towards the minimum amount required. Observe closely for signs of respiratory despair and sedation.
benzhydrocodone/acetaminophen and diazepam both equally raise sedation. Prevent or Use Alternate Drug. Limit use to patients for whom alternative therapy choices here are insufficient
If unable to stay clear of coadministration of belzutifan with delicate CYP3A4 substrates, look at expanding the sensitive CYP3A4 substrate dose in accordance with its prescribing data.